Providing modern healthcare to rural people in Bangladesh is still a far-reaching goal due to economic constraints. Hence, people mainly depend on the locally available plant materials to cure various health   disorders. Plant possesses components which render beneficial properties.(Tanabe et al 2002) Therefore, currently attention is being drawn towards exploring plant sources for substances that provide nutritional and pharmaceutical advantages to humans. Green leafy vegetables are a good source of minerals and vitamins.(Rahman et al 2010). The use of natural products as medicinal agents presumably predates the earliest recorded history. Moringa oleifera is a plant which is used in several traditional medicine systems to cure various diseases. These plant has been known to possess some medicinal resources as Antimicrobial activity, wound healing effect, antidiabetic effect, antioxidant activity, Nephroprotective activity, anti-carcinogenic properties, Anti-inflammatory Activity, immunomodulatory effects,  Antifertility Activity, Hepatoprotective Activity, cardio-protective effect, Anti-ulcer Activity, Antipyretic and Analgesic activity, Anthelmintic, Diuretic , Antiurolithiatic, CNS Activity, Local Anaesthetic Activity and other miscellaneous activities. The extracts from Moringa oleifera leaf can be a source of natural antimicrobials with potential applications in pharmaceutical industry to control coliform bacteria. .(Rahman et al 2010).A wide range of chemical compounds are found in these plants. The pharmacological studies reported in the present review confirm the therapeutic value of Moringa oleifera. Thus the use of this plant for human and animal disease therapy and reinforce the importance of the ethno-botanical approach as a potential source of bioactive substances.

Background:Recent data suggest that Bivalirudin provides ischemic protection superior to Heparin,and comparable to Heparin plus glycoprotein IIb/IIIa inhibitors, with significantly fewer bleeding complications. Whetherthis advantage persists in large population has not beenfully defined.

Objective: This study systematically evaluates clinical outcomes of treatment with Bivalirudinvs Heparin in patients of acute coronary syndrome undergoing Percutaneous coronary interventions (PCI).

Methods: We analyzed prospective, randomized controlled trials via electronic searches that have reported clinical outcomes at 7 and 30 days. The outcomes were major bleeding, net clinical outcomes and Major Adverse Cardiac Events – MACE. Data from individual trials were combined by a meta analysis method of Mantel-Haenszelcalculate a relative risk (RR) and 95% confidence interval (95%CI) across the studies.Theheterogeneity across the trials was assessed through χ² statistic, I² andvisual inspection of the forest plots.

Results: This meta-analysis involved a total of 30,088 patients (Bivalirudin, n=15,105; Heparin, n=14,983). Compared with Heparin, Bivalirudin was associated with a lower risk of major bleeding (RR 0.38; 95%CI 0.29-0.48 at 7 days and RR 0.67;95%CI 0.60-0.75 at 30 days), net clinical outcomes (RR 0.56; 95%CI 0.47-0.66 at 7 days and RR 0.89; 95%CI 0.83-0.96 at 30 days) and MACE (RR 0.78; 95%CI 0.63-0.96 at 7 days). There was no significant difference in case of MACE at 30 days (RR 1.02; 95%CI 0.93-1.11).  Heterogeneity was observed across the trials that reported major bleeding (χ²=14.71, 5 df, p=0.01, I²=66%) at 30 days, but not at 7 days for reported major bleeding, and also for net clinical outcomes and MACE both at 7 days and 30 days.

Conclusion: This analysis further supports that Bivalirudin provides significantimprovement in net clinical outcomes and MACE with a significant reduction of bleedingcomplications.

The liver is an organ of utmost importance, which plays a vital role in the metabolism of drugs entering the body. A variety of drugs and plant extracts were evaluated for their hepatoprotective activity. Present study was undertaken to ascertain the hepatoprotective effect of dried leaves of Pongamia pinnata. Chloroform and ethanolic extract of dried leaves of Pongamia pinnata was evaluated and subjected for hepatoprotective activity in two doses of 250mg and 500mg in wistar strain of albino rats against CCl₄ induced hepatic damage. SGOT, SGPT, ALP and total Bilirubin were used as biochemical marker for assessment of the activity. The Chloroform     500 mg and ethanolic extract 250 mg has found significant hepatoprotective activity by virtue of lowering the marker enzymes like SGPT, SGOT and ALP.

Hypertension using β adrenergic antagonist and Diuretic as first line therapy is associated with risk of NIDDM due to weight gain, Attenuation of the beta receptor mediated release of insulin from pancreatic beta cell, Decreased blood flow through the microcirculation in skeletal muscle tissue leading to decreased insulin sensitivity and impair insulin stimulated uptake of glucose in peripheral tissues