Research-Based Strategies for Teaching Vocabulary

2023-08-18T12:53:19+00:00

Vocabulary and successful reading comprehension appear to be intertwined, according to top researchers in the field. This paper will explore research about the latest methods that are proven to work in vocabulary instruction and how to effectively implement them in the classroom. Experts in the field will be identified and their findings explored in this crucial area of literacy. Strategies and techniques along with ways to integrate technology to enhance learning will be provided to give a complete vision of the process of teaching vocabulary, and thus improve reading comprehension.

Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach

2023-08-18T12:56:04+00:00

Diabetes is the fifth leading cause of death in most developed countries. In spite of this, the drugs available in the market for treatment of diabetes are more expensive with side effect. Therefore, there is a high demand of cost-effective novel natural antidiabetic drug without any side effect. In our investigation, we studied in silico the mechanism of secondary metabolites isolated from S. persica which modify the enzyme action, their in vitro inhibitory activity of alpha amylase and the phyto-constituent analysis those are responsible for its activity. In silico study revealed that kaempferol from S. persica is a most effective metabolite which can bind, interact and modulate the activity of all enzymes with much higher binding affinity and lesser binding energy such as -4.58 kcal/mol for alpha amylase, -4.76 kcal/mol for beta glucosidase, -4.97 kcal/mol for glycogen synthase kinase, -4.3kcal/mol for glucokinase and -3.85 kcal/mol for alpha glucosidase. Aqueous extract of S. persica has a high ability with 72.39% inhibition value to inhibit the activity of alpha amylase and 376μg /ml IC₅₀ value in comparison with standard drug which show 65.99% inhibition value. Total 15 compounds have been detected in TLC analysis in different solvent system and different extracts. Kaempferol might be one of them, which attribute to the anti-diabetic property. Further purification and characterization of kaempferol is required, which may prove a probable anti-diabetic drug

Journal of Life Science and Biotechnology

Research-Based Strategies for Teaching Vocabulary

Exploiting the therapeutic potential of secondary metabolites from Salvadora persica for diabetes using in silico and in vitro approach