The integration of data engineering and artificial intelligence (AI) has emerged as a transformative force in healthcare, enabling predictive analysis that significantly improves patient outcomes, operational efficiency, and cost management. This study proposes a robust predictive analysis framework that combines advanced data engineering techniques with AI models to address the inherent complexities of healthcare data. Healthcare systems generate vast and heterogeneous data from electronic health records (EHRs), imaging modalities, wearable devices, and laboratory results, presenting challenges such as data fragmentation, interoperability, and scalability. Leveraging data engineering, the framework ensures seamless data ingestion, preprocessing, and storage, creating a unified pipeline that supports real-time analytics. AI algorithms, including machine learning (ML) and deep learning models, are then employed to derive actionable insights for disease prediction, resource optimization, and personalized treatment strategies.The proposed framework is validated using diverse healthcare datasets, demonstrating high predictive accuracy, scalability, and practical applicability. It outperforms existing models by addressing critical limitations, such as handling data silos, ensuring data privacy, and adapting to varying clinical workflows. Furthermore, the study discusses the ethical implications and potential challenges, including data security and algorithmic biases, while suggesting future directions to refine the framework. This integration of data engineering and AI has the potential to revolutionize healthcare by enabling predictive, preventive, and precision medicine.