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Cord Blood Stem Cells: A New Hope for Treating Neonatal Hypoxic Ischemic Encephalopathy Induced by Gestational Diabetes Mellitus

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· Pages: 1-9· (2023)· Published: June 30, 2023
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Abstract

Neonatal hypoxic ischemic encephalopathy (HIE) is a severe neurological condition that can cause long-term neurodevelopmental disabilities and is a significant cause of morbidity and mortality in neonates. Gestational diabetes mellitus (GDM) is a risk factor for HIE, and affected infants are at increased risk of long-term neurodevelopmental deficits. Currently, there are limited treatment options for HIE. However, stem cell therapy has emerged as an encouraging approach for treating HIE. Cord blood stem cells (CBSCs) have been shown to have neuroprotective and regenerative properties and have been used in clinical trials for the treatment of HIE. CBSCs have the potential to regenerate damaged tissue in the brain, provide neuroprotection, and have a low risk of immune rejection. Additionally, CBSC transplantation is a safe and non-invasive procedure that has a lower risk of complications compared to other treatment modalities. The use of CBSCs for the treatment or management of neonatal HIE induced by GDM holds great promise for improving neurological outcomes and reducing long-term neurodevelopmental deficits. However, further studies are needed to confirm the safety and efficacy of CBSC transplantation and to establish the optimal timing, dose, and frequency of transplantation. Overall, CBSC transplantation represents a hopeful approach for the treatment or management of neonatal HIE induced by GDM.

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Author details
David Leung
Group Laboratory Operations, Cordlife Group Limited, Singapore 768160, Singapore
✉ Corresponding Author
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Ho-Chuen Leung
Group Laboratory Operations, Cordlife Group Limited, Singapore 768160, Singapore
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Chin-Fung Yeung
Group Laboratory Operations, Cordlife Group Limited, Singapore 768160, Singapore
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